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The count data were filtered to remove genes with low expression, transformed using the variance stabilizing transformation from the DESeq2 package (51), and then batch corrected using ComBat (52)

postulated the role of indoxyl sulfate in the pathogenesis of renal anemia: indoxyl sulfate could stimulate oxidative stress and induce eryptosis through Organic Anion Transporter 2 (OAT2)- and NADPH oxidase-dependent, as well as GSH-independent mechanisms [257]

Metabolism 56 , 8793 (2007)

These bifunctional molecules link a ligand for the target protein to a ligand recruiting an E3 ubiquitin ligase, such as VHL, MDM2, CRBN, or IAPs